Thyrotoxic Periodic Paralysis and Polymorphisms of the ADRB2, AR, and GABRA3 Genes in Men with Graves Disease

Thyrotoxic Periodic Paralysis and Polymorphisms of the ADRB2, AR, and GABRA3 Genes in Men with Graves Disease

BACKGROUND Thyrotoxic periodic paralysis (TPP) is a rare complication of thyrotoxicosis characterized by acute attacks of muscle weakness and hypokalemia. Recently, variation in several genes was suggested to be associated with TPP. This study evaluated the genetic predisposition to TPP in terms of the β2-adrenergic receptor (ADRB2), androgen receptor (AR), and γ-aminobutyric acid receptor α3 s...

Evaluating the Efficacy of Primary Treatment for Graves' Disease Complicated by Thyrotoxic Periodic Paralysis

Objective. Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of Graves' disease (GD). The present study compared the long-term efficacy of antithyroid drugs (ATD), radioactive iodine (RAI), and surgery in GD/TPP. Methods. Sixteen patients with GD/TPP were followed over a 14-year period. ATD was generally prescribed upfront for 12-18 months before RAI or surgery ...

Thyrotoxic periodic paralysis.

Periodic flaccid paralysis of skeletal muscle occurring in a thyrotoxic patient, an unusual and dramatic event, is seen predominantly in Oriental men. It is important to remember the clinical association between periodic paralysis and thyrotoxicosis.

Thyrotoxic periodic paralysis.

Thyrotoxic periodic paralysis and chorea: two uncommon neuromuscular complications in an adolescent with newly diagnosed Graves disease

Both thyrotoxic periodic paralysis (TPP) and choreoathetosis are unusual complications of childhood thyrotoxicosis. We hereby report a boy who presented with both TPP and choreoathetosis at the initial presentation of his Graves disease. A 14 year-old Thai boy presented with acute generalized proximal muscle weakness and myalgia for 5 hours. Detailed history revealed the increased appetite, hea...